References
PRP vs. HA — Exclusion Criteria References · Report created 1/7/2026 · 178 entries
Marcel Tschopp, ..., and A. Rosskopf
Investigative Radiology · 2024
Demonstrates a randomized, double-blinded, placebo-controlled MRI study of IA injections in knee OA. Compares intra-articular glucocorticoid, hyaluronic acid, PRP, and placebo with quantitative T2/T2 mapping and morphological MRI at baseline, 3 and 12 months. Relevant: adult mild–moderate knee OA (KL 1–3); reports structural (cartilage T2/T2, Outerbridge, BMLs, cysts, osteophytes) outcomes; clinical and safety outcomes not specified in abstract—check full text for pain/function/safety data.
M. Tschopp, ..., and A. Rosskopf
Investigative Radiology · 2022
Compares clinical outcomes of IA glucocorticoid, hyaluronic acid, PRP, and placebo in knee OA. Conducts a double-blind, placebo-controlled RCT (n=120 knees, KL grade 1–3) with pain (NRS) over 6 months plus WOMAC, activity, mobility, and adverse events. Relevant: adult knee OA RCT (2022), includes placebo arm and reports clinical and safety outcomes; structural outcomes not mentioned in abstract.
K. Bennell, ..., and David J. Hunter
JAMA · 2021
Demonstrates a randomized, placebo-controlled trial of intra-articular PRP for knee OA. Compares 3 weekly leukocyte-poor PRP injections versus saline placebo in 288 adults (KL 2–3), double-blinded, 12-month follow-up. Relevant: knee-specific RCT (2021), reports clinical (pain) and structural (medial tibial cartilage volume) outcomes and safety; PRP preparation specified (commercial leukocyte-poor).
José Carlos Nunes-Tamashiro, ..., and R. N. V. Furtado
Clinical Rehabilitation · 2022
Compares intra-articular PRP versus triamcinolone hexacetonide and saline in knee OA (double-blind RCT). Randomized 100 patients with KL II–III OA, blinded patients/assessor, assessed pain, function, QoL at 4,8,12,52 weeks; baseline and 52-week radiographs. Relevant: includes placebo (saline) and active CS comparator, reports clinical outcomes over 1 year; radiographic outcomes limited to baseline vs 52 weeks.
M. Ghadamzadeh, ..., and Paniz Jahani
Archives of Bone and Joint Surgery · 2025
Demonstrates a randomized, double-blind trial comparing single- and double-centrifuged PRP versus saline placebo in knee OA. Enrolled 63 patients with KL grade 2–3 OA, randomized to single-PRP, double-PRP, or normal saline; assessed MRI, VAS, WOMAC, ROM, and function at baseline and 6 months. Relevant: direct IA PRP vs placebo RCT (2025), reports clinical and MRI structural outcomes at 6 months; sample size modest, MRI endpoints limited to selected cartilage sites and WORMS components.
A. Qamar, ..., and S. Danish
Pakistan Journal of Medical and Health Sciences · 2021
Demonstrates a randomized, double-blind, placebo-controlled trial of intra-articular PRP. Randomized 50 participants (100 knees) to 3 weekly IA injections of 5 mL autologous PRP versus 5 mL saline; pain measured by VAS. Relevant as a 2019–2021 trial of PRP vs saline in adult knee OA, but provided excerpt reports only short-term VAS results (1 month); no structural or safety data shown here.
M. Dório, ..., and R. Fuller
Journal not specified · 2021
Demonstrates a double-blind, randomized, placebo-controlled trial of intra-articular PRP and plasma for knee OA. Compares 2 ultrasound-guided IA injections (PRP vs plasma vs saline) with primary outcome VAS pain at 24 weeks, plus KOOS, OMERACT-OARSI, TUGT. Relevant: adult KOA RCT (n=62) 2021, placebo (saline) comparator, reports clinical outcomes to 24 weeks; small sample, mostly female, no structural or long-term safety/TKA data mentioned.
A. Sadeghi, ..., and A. Ammari
Journal not specified · 2021
Demonstrates a within-person randomized, double-blind comparison of IA PRP versus placebo. Enrolled 30 patients with bilateral knees matched radiographically; one knee received single PRP injection, contralateral knee received saline; outcomes at baseline and 6 weeks (WOMAC subscales, VAS). Relevant: adult knee OA RCT (2021), placebo-controlled and double-blind, reports clinical outcomes and short-term safety implicitly; small sample, single injection, short 6-week follow-up, and inter-knee comparisons showed within-knee improvements with PRP but no significant between-knee differences on WOMAC.
Hamid Reza Beiki, ..., and J. Moghimi
Journal of Preventive Epidemiology · 2024
Demonstrates a double-blind, randomized within-subject trial of intra-articular PRP versus sham. Randomized each knee of 34 patients (KL grade 2–3) to 3 mL PRP injection or needling-only; outcomes at 3 and 6 months (WOMAC, IKDC, EQ-VAS, TAS). Relevant: 2024 RCT vs sham/placebo, adult knee OA, reports clinical outcomes (pain/function); no structural or safety outcomes reported in provided excerpt.
S. A. Raeissadat, ..., and S. Payami
Journal of Pain Research · 2020
Demonstrates a randomized, within-patient trial of intra-articular PRP versus control in knee OA. Compares two PRP injections (4-week interval) to contralateral control knees in 23 patients, assessing VAS, WOMAC, and MRI cartilage features at baseline and 8 months. Relevant: adult knee OA (KL grades 1–3), double-blind, MRI structural outcomes reported; small sample (46 knees, all female), control details unclear (presumably saline/sham), limits generalizability.
Xiaochen Qiao, ..., and Zhi Tian
BMC Musculoskeletal Disorders · 2023
Demonstrates a 2023 systematic review and Bayesian network meta-analysis of IA CS, HA, PRP (and combos) for knee OA. Searches multiple databases to Dec 2022, includes 35 randomized trials (n=3,104), extracts VAS, WOMAC, and adverse events; uses Bayesian random-effects NMA. Relevant: focuses on knee OA RCTs vs various comparators (includes placebo arms), reports clinical outcomes and safety but limited to trials dDec-2022; check heterogeneity, PRP/HA product details, and risk-of-bias assessments for applicability.
Yuan Xue, ..., and Y. Xue
Medicine · 2023
Conducts a network meta-analysis comparing intra-articular agents for mild–moderate knee OA. Pooled randomized trials through Dec 20, 2021 across seven databases, using VAS and WOMAC change as primary outcomes. Relevant as an evidence synthesis (2023) including IA agents, but cutoff 2021 means it excludes 2022–2026 trials; check whether analyses separate HA, PRP, and corticosteroids and whether comparisons include placebo/sham or standard-care arms.
Jiahao Zhang, ..., and Jiacheng Li
Frontiers in Medicine · 2025
Demonstrates a Bayesian network meta-analysis comparing ultrasound-guided intra-articular injections for knee OA. Pools 14 RCTs (934 patients) of US-guided PRP, HA, corticosteroids, ozone, dexamethasone, autologous adipose tissue, and placebo; primary outcomes VAS and WOMAC. Relevant as an evidence synthesis (2025) including placebo-controlled US-guided IA arms; check whether knee-only RCTs, PRP/HA/CS trial counts, structural and safety outcomes, and risk-of-bias details are reported.
Nikhil Gupta, ..., and K. Bansal
Journal of Orthopaedic Surgery and Research · 2025
Performs a Bayesian network meta-analysis of long-term IA injectables for knee OA. Pools 37 RCTs (n=5,089) with e1 year follow-up to compare PRP, HA, CS, and combinations on pain and function. Relevant: RCTs only, knee OA–specific, mid/long-term outcomes (e12 months); unclear if structural or safety outcomes were included.
E. Mameri, ..., and Jorge Chahla
Orthopaedic Journal of Sports Medicine · 2024
Compares efficacy of IA PRP, HA, CS, and BMAC versus placebo via network meta-analysis. Pooled 47 RCTs (level I–II) with e6-month follow-up, using arm-based Bayesian random-effects NMA on 0–100 pain/function scores. Relevant as a 2024 evidence synthesis including knee OA RCTs versus placebo; check whether knee-only trials, handling of heterogeneous PRP/HA products, and structural/safety outcomes were reported (paper focuses on pain/function).
Harshvivek Singh, ..., and J. Chahla
The American Journal of Sports Medicine · 2021
Compares efficacy of IA HA, CS, PRP, and PRGF for knee OA via network meta-analysis. Conducts a PRISMA systematic review and network meta-analysis of RCTs, extracting 6-month pain/function outcomes (converted to 0–100 scales). Relevant as a 2021 evidence synthesis including HA, PRP, and corticosteroids versus comparators, but check whether analyses separate placebo/sham or standard-care comparators and structural/safety outcomes (abstract reports clinical pain/function at 6 months only).
Saad Khalid, ..., and Pratik Bhattarai
Annals of Medicine and Surgery · 2023
Compares PRP vs other IA therapies in knee OA via meta-analysis. Pools 42 RCTs (search to Mar 2023) extracting WOMAC, VAS, KOOS, IKDC at 1–12 months, with subgroup, heterogeneity, and bias assessments. Relevant as a 2020–2023 evidence synthesis including trials vs placebo/CS/HA, but check if knee-only data were separable and whether PRP/HA/CS arms versus placebo/standard care were reported separately.
G. Filardo, ..., and A. Grassi
Cartilage · 2020
Demonstrates a systematic review and meta-analysis of RCTs comparing intra-articular PRP for knee OA versus placebo/sham and other injectables. Achieves this by pooling 34 randomized trials (1403 PRP knees, 1426 controls) through a PROSPERO-registered search to Jan 17, 2020, using Cochrane risk-of-bias and GRADE. Relevant: reports clinically and statistically greater pain/function benefit for PRP vs placebo at 12 months and vs HA/CS at 6–12 months; structural and safety outcomes not clearly reported in the abstract.
L. A. Costa, ..., and M. Ferretti
The American Journal of Sports Medicine · 2022
Presents a systematic review and meta-analysis comparing intra-articular PRP to other nonsurgical therapies for knee OA. Pools 40 randomized/quasi-randomized trials (n=3035) up to Jan 2021, comparing PRP vs HA, corticosteroid, and saline; assessed risk of bias (Cochrane) and GRADE. Relevant as an evidence synthesis (2022) covering PRP vs placebo/sham (saline) and standard comparators; check included trials’ dates (d2020), PRP preparation heterogeneity, outcomes (pain, function, treatment failure), and GRADE risk-of-bias details for applicability to 2020–2026 review.
Alessandro Bensa, ..., and G. Filardo
The American Journal of Sports Medicine · 2025
Analyzes PRP versus placebo RCTs for knee OA focusing on clinical significance (MCID) and platelet concentration effects. Performs a PRISMA-guided meta-analysis of randomized placebo-controlled trials across five databases, pooling VAS and WOMAC at 1, 3, 6, and 12 months, with platelet-concentration subgroup analyses. Relevant: 2025 evidence synthesis limited to placebo-controlled RCTs (meets primary criteria); reports clinical outcomes and concentration moderators but unclear if structural or safety outcomes were included—check full text for structural endpoints, safety reporting, trial selection, and platelet-preparation definitions.
Mao Hong, ..., and Wanshou Guo
BioMed Research International · 2021
Analyzes the efficacy and safety of intra-articular PRP for knee osteoarthritis. Conducts a 2021 systematic review and meta-analysis (search to Dec 2019) of 23 RCTs comparing IA PRP with placebo or conservative comparators (NSAIDs, HA, CS); primary outcomes VAS, WOMAC, IKDC; adverse events reported. Relevant to your criteria: includes RCTs vs placebo/sham and standard care, finds PRP superior on several clinical outcomes at ~6 months with no higher adverse-event rate; cutoff Dec 2019—trials 2020–2026 are not covered.
Liu-yan Nie, ..., and Jing Xue
Orthopaedic Journal of Sports Medicine · 2021
Synthesizes RCT evidence on intra-articular PRP for knee osteoarthritis. Performs a systematic review and random-effects meta-analysis of 21 RCTs (search to Mar 2019) comparing PRP versus saline, corticosteroid, and HA. Relevant as a 2021 evidence synthesis showing clinically important pain/function benefits of PRP vs saline and vs steroid, inconclusive PRP vs HA; heterogeneity in PRP preparations noted and structural/safety outcomes not clearly reported.
Thomas Joanna, ..., and Athanasiou Anastasia
SVOA Orthopaedics · 2023
Demonstrates a systematic review of intra-articular PRP versus placebo for knee OA. Pools 12 RCTs (PubMed/Cochrane/CINAHL search, two reviewers, PRISMA/Covidence) reporting 6-month WOMAC stiffness, VAS, KOOS improvements favoring PRP. Relevant limitations: substantial heterogeneity in PRP prep and patients, no structural imaging or TKA outcomes reported, safety outcomes not summarized, and focus is PRP vs saline only.
Jack L Crowley and V. Soti
Cureus · 2023
Summarizes recent clinical trial evidence on intra-articular PRP for knee osteoarthritis. Systematic review (PRISMA; searched PubMed/Embase/Orthogate/ClinicalTrials.gov to July 2023) of clinical trials in prior five years, extracting clinical (VAS/WOM-AC/function) and some MRI structural outcomes. Relevant: includes randomized PRP vs saline trials (e.g., Bennell 2021, Dório 2021), highlights heterogeneity in PRP preparation/dosing and platelet concentrations, reports no clear MRI cartilage benefit and no pooled meta-analysis.
Millsep Sieroka and Sherrina Oktaviani Gosandra
The International Journal of Medical Science and Health Research · 2025
Synthesizes RCT evidence on intra-articular PRP for knee osteoarthritis. Conducts a PRISMA-guided systematic review of RCTs comparing PRP versus saline, HA, or corticosteroids, extracting WOMAC, VAS and other functional outcomes. Relevance notes: published 2025 (within 2020–2026); appears focused on knee-specific RCTs versus placebo/active comparators, but check included trials list, risk-of-bias assessment, PRP preparation heterogeneity, and whether structural or safety outcomes were fully reported.
Association of North America and the International Arthroscopy Association
2025
No summary or abstract available
A. Najm, ..., and F. Berenbaum
Annals of the Rheumatic Diseases · 2021
Demonstrates a systematic review and meta-analysis of IA corticosteroid injections for knee OA. Pooled 14 RCTs (from 23 SLR-included studies) comparing IA GC versus HA, saline/placebo, IA/oral NSAID, or physiotherapy; reported SMDs by short (<6w), medium (6–24w), long (>24w) follow-up. Relevant: conference abstract (2021) with limited detail; short-term pain/function favored GC (SMDs ~0.61 and 1.02, CIs wide), no medium-term benefit, long-term favored comparators (heterogeneous, driven by single large trials); safety reported in 18 studies with some cartilage loss signal in one trial.
Haijiang Ren, ..., and Wenlai Guo
The Journal of International Medical Research · 2020
Analyzes the clinical efficacy of intra-articular PRP for knee osteoarthritis. Performs a 2020 meta-analysis (5 RCTs, 320 patients) using PubMed/Embase/Cochrane search and RevMan pooling. Relevant: mostly symptom outcomes with mixed results (some VAS/WOMAC improvements and higher satisfaction); only two RCTs used saline placebo (others HA), no structural or detailed safety data reported, and PRP preparation details are not described.
Alessandro Bensa, ..., and Giuseppe Filardo
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
Compares safety profiles of IA corticosteroids, hyaluronic acid, PRP, and cell-based injections. Conducts a PRISMA systematic review and meta-analysis of adverse events from clinical studies (559 studies, 76,061 patients). Relevant as an evidence synthesis (2025) focused on safety outcomes; check whether analyses stratify randomized placebo/sham-controlled trials and report clinical/structural outcomes (this paper centers on adverse events).
Alessandro Bensa, ..., and G. Filardo
EFORT Open Reviews · 2024
Compares clinical effectiveness of intra-articular corticosteroids versus hyaluronic acid and PRP in knee OA via systematic review/meta-analysis. Pools 35 RCTs (n=3348) per PRISMA, assessed RoB-2 and GRADE; compares WOMAC, VAS up to 12 months and evaluates MCID. Relevant as a 2024 evidence synthesis of RCTs, but it appears to be head-to-head CS vs HA/PRP (not necessarily versus placebo/sham or standard care); check included trials for placebo arms, structural or safety outcomes reporting, and heterogeneity of HA/PRP preparations.
Adnan Haider, ..., and Yazdan Bin Kamran³
Journal of Health, Wellness and Community Research · 2025
Demonstrates a systematic review and meta-analysis comparing IA hyaluronic acid vs corticosteroids for knee OA. Conducts PRISMA-aligned search (2013–2025), pools 18 RCTs using random-effects SMDs for pain (VAS) and function (WOMAC) across short- and long-term intervals. Relevant as an evidence synthesis (2025) of RCTs; however it compares HA vs CS (not placebo/sham/standard-care arms explicitly), so check included trials for placebo-controlled arms and for reporting of structural and safety outcomes.
of North America and the International Arthroscopy Association
2024
No summary or abstract available
S. A. Raeissadat, ..., and M. Darvish
BMC Musculoskeletal Disorders · 2021
Compares clinical effects of IA PRP, PRGF, HA, and ozone in knee OA. Randomized 238 patients (200 analyzed) with mild–moderate knee OA into four active IA arms; measured VAS, WOMAC, Lequesne at 2, 6, 12 months. Relevant but somewhat related only: head-to-head trial with no placebo/sham or standard-care control reported; no structural outcomes or safety data provided in excerpt.
F. A. Idres and M. Samaan
Annals of Medicine and Surgery · 2023
Compares intra-articular PRP versus corticosteroid injections for knee OA (systematic review). Synthesizes nine randomized controlled trials identified from PubMed and CENTRAL, extracting WOMAC/KOOS/VAS outcomes for early–mid follow-up. Relevance notes: 2023 evidence synthesis of RCTs is directly relevant, but scope excludes HA and placebo-only arms; check included trials for comparator types (some may be head-to-head PRP vs CS rather than vs placebo/sham/standard care) and for reporting of structural/safety outcomes.
M. McLarnon and N. Heron
BMC Musculoskeletal Disorders · 2021
Compares intra-articular PRP versus intra-articular corticosteroid injections for knee OA. Performs a systematic review and random-effects meta-analysis of 8 RCTs (n=648), searches to June 2020, Cochrane RoB (overall low). Relevant for clinical efficacy (WOMAC/VAS): PRP superior to CS at 3–9 months (largest SMDs at 6–9 months); structural and safety outcomes not reported in provided summary.
M. McLarnon and N. Heron
Rheumatology · 2023
Compares intra-articular PRP versus corticosteroid injections for knee OA (systematic review/meta-analysis). Pools RCTs and controlled trials through June 2020 using random-effects SMDs for WOMAC, VAS, KOOS; risk-of-bias assessed with Cochrane tool. Relevant but somewhat limited: comparator is CS (not placebo/sham or standard-care); search cutoff June 2020 and published 2023, so it does not include 2020–2026 trials after June 2020.
Abbas Ahmadi, ..., and E. Espahbodi
Archives of Anesthesia and Critical Care · 2024
Compares leukocyte-poor PRP versus intra-articular corticosteroid injections for knee OA. Randomized controlled trial of 40 patients (2 groups of 20) receiving LP-PRP (from 40 cc blood, two-step centrifugation) or IA corticosteroid; reports clinical outcomes. Relevance caveats: small sample, unclear blinding/randomization details and comparator is active (CS) not placebo/sham or standard-care; adult knee OA population fits scope but lacks placebo arm and may be underpowered.
S. Saidapur, ..., and Satish Bachchu
IP International Journal of Orthopaedic Rheumatology · 2021
Compares intra-articular PRP versus triamcinolone in knee OA (randomized clinical trial). Randomized 70 adults with KL grade 1–2 knee OA to PRP (5 mL) or triamcinolone (80 mg), two injections 3 weeks apart; assessed VAS, KOOS, WOMAC at 3w, 3m, 6m. Relevant but somewhat limited for your criteria: head-to-head (PRP vs steroid), not versus placebo/sham or standard care; no structural or detailed safety outcomes reported in excerpts.
G. Arliani, ..., and Victor Otávio Oliveira
Revista Brasileira de Ortopedia · 2021
Compares intra-articular PRP versus HA for primary knee osteoarthritis. Randomized trial of 29 patients assessing VAS pain and WOMAC function; adverse events recorded. Small preliminary RCT (no placebo/sham or standard-care arm), no structural outcomes reported, limited sample and follow-up details.
Yu-Ning Peng, ..., and Carl P. C. Chen
Knee Surgery & Related Research · 2025
Compares clinical efficacy of leukocyte-poor PRP versus hyaluronic acid for knee OA (systematic review and meta-analysis of RCTs). Synthesizes 12 randomized trials (searched PubMed/Web of Science/Cochrane) using WOMAC, VAS, IKDC, EQ-VAS and adverse events; finds LP-PRP superior on WOMAC total/physical at 6 and 12 months and VAS at 3–12 months. Relevance note: this is a 2025 evidence synthesis but is a head-to-head PRP vs HA comparison (no placebo/sham or standard-care comparator); only leukocyte-poor PRP pooled—so it is somewhat related but does not address PRP/HA versus saline/sham or standard care.
Lili Chen, ..., and Jinshen He
Therapeutic Advances in Musculoskeletal Disease · 2023
Compares efficacy of PRP versus HA for osteoarthritis via meta-analysis. Pooled 30 RCTs (n=2733) from 4 databases to analyze WOMAC, VAS, IKDC, AEs, satisfaction, plus PRP subgroups. Relevance caveats: includes OA broadly (not specified knee-only here), is head-to-head PRP vs HA (no placebo/sham/standard-care arms), and spans varying PRP/HA preparations and injection schedules.
J. W. Belk, ..., and E. McCarty
The American Journal of Sports Medicine · 2020
Compares PRP versus HA for knee OA via systematic review and meta-analysis. Pools 18 randomized (level-1) trials (nH811 PRP patients), synthesizing WOMAC, VAS, and IKDC outcomes; subgrouped leukocyte-poor vs rich PRP. Relevant as an evidence synthesis (2020) of RCTs comparing PRP to HA (not placebo/sham); does not address PRP/HA versus saline/standard-care controls.
Kian Bagheri, ..., and Amir A Jamali
Journal of Experimental Orthopaedics · 2025
Compares PRP versus hyaluronic acid (HA) via systematic review and meta-analysis of RCTs. Pools randomized controlled trials to evaluate patient-reported outcomes at 6- and 12-month follow-up, and examines platelet concentration effects. Relevance note: This is a 2025 evidence synthesis but is head-to-head (PRP vs HA) — it lacks placebo/sham or standard-care comparator arms, so it is only somewhat related to the requested scope unless individual included trials contain placebo/standard-care arms or report knee-only data.
Adel Azzam, ..., and Khaled Amer
Al-Azhar International Medical Journal · 2022
Compares PRP versus hyaluronic acid for knee OA in a randomized trial. Randomized 40 adults to three weekly intra-articular injections (PRP n=20, HA n=20) and measured ROM, WOMAC, and VAS at baseline and 4 weeks after the third injection. Relevant limitations: no placebo/sham or standard-care control (head-to-head only), short follow-up (only 4 weeks reported), no structural outcomes or safety/ad-verse-event data presented.
Atef Mohamed Fathy Elbeltagy, ..., and M. Abdel-Samei
QJM: An International Journal of Medicine · 2021
Compares PRP versus hyaluronic acid for knee osteoarthritis via systematic review and meta-analysis. Pools clinical trials to assess efficacy and safety, reporting greater PRP benefit on WOMAC pain/function/stiffness at 6–12 months. Relevance caveats: head-to-head PRP vs HA (no placebo/sham/standard-care comparator); published 2021; check included trial designs, risk-of-bias, PRP preparation heterogeneity, and whether knee-only RCTs were isolated.
Hong Xu, ..., and Zhuang Wei
BMC Musculoskeletal Disorders · 2025
Compares clinical efficacy and safety of intra-articular HA versus PRP in knee osteoarthritis. Performs a systematic review and meta-analysis of 42 randomized controlled trials pooling VAS, WOMAC, and safety outcomes using RevMan. Relevance caveats: this is a head-to-head HA vs PRP synthesis (2025) — it does not compare either treatment against placebo/sham or standard-care controls, and heterogeneity in PRP/HA preparations and risk-of-bias details will determine applicability.
M. El sayed, ..., and Androw Shenoda
Benha Medical Journal · 2022
Reviews comparative trials of IA PRP, HA, and corticosteroid injections for knee OA. Performs a systematic search (Jan 2010–Mar 2021) and includes 30 trials (nH3303) comparing PRP vs HA, HA vs CS, and combinations. Relevance limits: published 2022 (search ends Mar 2021); includes randomized and nonrandomized trials, but many comparisons are head-to-head (few/no placebo/sham or standard-care arms specified), and trial heterogeneity/quality not detailed.
Yongqing Xiong, ..., and Wei Li
Frontiers in Medicine · 2023
Analyzes the pooled efficacy and safety of PRP injections for osteoarthritis. Conducts a PRISMA-style meta-analysis of 24 RCTs (n=1,344) searching major databases to March 2023. Relevant but partially off-scope: includes mixed joints (knee + hip/ankle/TMJ), focuses on PRP vs various comparators (including saline and CS); knee-only, structural, and detailed safety outcome reporting not explicitly specified in the excerpt.
Gian Ivander and Yovita Anggono
Orthopedic reviews · 2024
Compares intra-articular PRP versus HA for knee osteoarthritis. Performs a PRISMA systematic review of prospective RCTs (2019–2022), selected 23 studies and highlighted four high-quality pRCTs, using modified Jadad and RoB-2 assessments. Relevant but limited: focuses on PRP vs HA head-to-head (not placebo/sham); reports clinical outcomes (VAS, WOMAC, EQ-VAS, IKDC, Tegner) and risk-of-bias, but excerpts do not state inclusion of placebo/standard-care arms or report structural or safety endpoints.
S. Rodriguez-García, ..., and L. Carmona
RMD Open · 2021
Summarizes evidence from systematic reviews on intra-articular therapies for arthropathies. Conducts an overview of SRs (search to July 2020), including RCTs, assessing pain, function, and adverse events; AMSTAR-2 used for quality. Relevant: includes 18 SRs on knee OA (HA, CS, PRP discussed); search cutoff July 2020 (pre-2021 RCTs only) and full PRP conclusions not detailed here—useful as an evidence-synthesis but not a 2020–2026-only update.
Lin Yi, ..., and Guanghui Zhang
Frontiers in Physiology · 2025
Summarizes an overview of systematic reviews/meta-analyses on PRP for knee osteoarthritis. Reviews 29 SRs/MAs (searches to Dec 1, 2024), assessing overlap (GROOVE), SR quality (AMSTAR-2), and primary-trial risk (ROB 2.0). Relevant as a 2025 evidence synthesis of PRP for adult knee OA vs controls, but notes very high primary-study overlap and predominantly critically low SR quality.
D. Szwedowski, ..., and S. Jeka
Biomedicines · 2022
Demonstrates a randomized trial comparing PRP, HA, and corticosteroid injections for knee OA. Randomized, single-center, triple-parallel trial (n=75; 25 per arm) with single intra-articular leukocyte-poor PRP vs HA vs glucocorticosteroid; WOMAC measured baseline, 6, 12, 26 weeks. Relevant limitations: no placebo/sham or standard-care control arm, single injection only, radiographic OA included (KLH2), structural outcomes not reported, incomplete reporting here of blinding, steroid type/dose, and safety details.
Hirotaka Nakagawa, ..., and Walter I. Sussman
The American Journal of Sports Medicine · 2025
Assesses reporting quality of randomized trials of intra-articular PRP for knee OA against MIBO standards. Performs a PRISMA-guided systematic review of RCTs of PRP for knee osteoarthritis, scoring adherence to 23 MIBO checklist items. Relevant as a 2025 evidence synthesis focused on PRP RCT reporting (not a meta-analysis of efficacy); includes only RCTs with IA PRP but evaluates reporting completeness rather than clinical/structural/safety outcomes.
Qipeng Wu, ..., and B. Mi
Journal of Orthopaedic Surgery · 2020
Compares PRP versus hyaluronic acid efficacy in knee osteoarthritis via meta-analysis. Pools 10 randomized trials (searched to May 2018) comparing PRP vs HA on pain/function (IKDC, WOMAC, VAS/NRS, KOOS). Relevant but somewhat related only: knee-specific RCTs included, but no placebo/sham or standard-care control arms reported, no structural imaging outcomes, and limited safety reporting.
Gae Fattini Fellini, ..., and Giuseppe Filardo
Journal of Experimental Orthopaedics · 2025
Synthesizes sex-specific outcomes after intra-articular CS, HA, PRP, and cell therapies for knee OA. Conducts a systematic review and meta-analysis (2025) pooling trials to compare male vs female treatment responses across injection types. Relevant as an evidence synthesis (2020–2026 window) but scope includes cell-based therapies; need to confirm inclusion criteria: whether analyses restricted to RCTs/placebo-controlled knee-only trials and which outcomes (clinical, structural, safety) were reported separately by sex.
Y. Gökçeolu, ..., and Sedat Demir
Medicine · 2025
Compares clinical outcomes of intra-articular PRP, HA, CS, and NSAID injections for knee OA. Retrospective cohort of 205 knees (KL 2–3) treated 2016–2021; VAS and WOMAC at baseline and 6–12 month follow-up. Relevance: non-randomized, single-site retrospective design (2025); includes IA injections but lacks placebo/sham or standard-care control, limited structural outcome reporting (only KL grade), and no major safety signals reported.
Lichun Wang, ..., and S. Rastogi
Videosurgery and other Miniinvasive Techniques · 2022
Abstract: Introduction Due to the complicated surgical procedure of knee arthroplasty and low effectivity of hyaluronic acid (HA) in the treatment of knee osteoarthritis, various studies highly recommend the use of platelet-rich plasma (PRP). However, some studies also reported lower efficacy and limited use of PRP. Aim To analyze systematically the different randomized controlled trials (RCTs) comparing the effectiveness of HA vs. PRP for the treatment of knee osteoarthritis. Material and methods A systematic literature review was conducted using Medline and Central databases for RCTs about the comparison of HA vs. PRP for the treatment of knee osteoarthritis. Studies were included...
Dr. C Dinesh, ..., and Dr. A Manikandarajan
International Journal of Orthopaedics Sciences · 2020
Abstract: Aim: To compare the clinical and functional outcomes of treatment of mild to moderate osteoarthritis of knee joint by using intra-articular platelet-rich plasma injection versus hyaluronic acid injection. Methods: Total of 60 patients with grade 0 to grade 2 osteoarthritis were included in the study, of which 30 were treated with intra-articular PRP and the other 30 with intra-articular HA. Patients was evaluated before and after the procedure using Visual Analogue Scale (VAS) and Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) at 6, 12, 24 weeks respectively.Results: Both groups had clinical improvement but excellent results were seen in the group...
Iacopo Romandini, ..., and G. Filardo
The American Journal of Sports Medicine · 2024
Abstract: Background: Platelet-rich plasma (PRP) is increasingly used for the injection treatment of knee osteoarthritis (OA). However, the role of leukocytes contained in PRP is controversial, with some preclinical studies suggesting detrimental effects and others emphasizing their contribution in secreting bioactive molecules. Purpose: To compare the safety and effectiveness of leukocyte-rich PRP (LR-PRP) and leukocyte-poor PRP (LP-PRP) for the treatment of knee OA. Hypothesis: That leukocytes could influence results both in terms of adverse events and clinical outcomes. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This double-blind randomized controlled trial included 132 patients with Kellgren-Lawrence grade 1-3 knee...
Alessandro Bensa, ..., and G. Filardo
Journal of Experimental Orthopaedics · 2024
Abstract: The purpose of this study was to quantify and compare the clinical relevance of the different intraarticular corticosteroids (CS) effects in vivo for osteoarthritis (OA) treatment.
Yu-Ning Peng, ..., and A. Suputtitada
Pharmaceuticals · 2022
Abstract: (1) Background: To evaluate the clinical effects of leukocyte-rich platelet-rich plasma (LR-PRP) and hyaluronic acid (HA) injections in treating patients suffering from knee osteoarthritis (OA); (2) Methods: Randomized controlled trials (RCTs) were searched from PubMed, Web of Science, and Cochrane Library. Keywords were: platelet-rich plasma, LR-PRP, leukocyte-rich, hyaluronic acid, and knee osteoarthritis. The included RCTs were published between the 1st of November 2011 and the 3rd of February 2021. Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores, visual analog scale (VAS) scores, International Knee Documentation Committee (IKDC) scores, and adverse events were used as outcomes for evaluation; (3) Results:...
Anant Akash and U. Gupta
International Journal of Orthopaedics Sciences · 2020
Abstract: Background: Osteoarthritis (OA) of the knee is the most common chronic degenerative joint disease characterized by pain, stiffness, swelling and progressive functional limitation in elderly. Non-surgical management modalities like physical therapy, lifestyle modification and oral non-steroidal antiinflammatory drugs, are often ineffective or do not alleviate symptoms adequately. Intra-articular corticosteroid (CS) and hyaluronic acid (HA) injections have been used for long to alleviate the symptoms of knee OA. Recently platelet-rich plasma (PRP) therapy has also been tried widely. Very few researches involving a comparison of the three have been conducted. The purpose of the present study was to evaluate the therapeutic...
E. Holguin
Orthopaedic Journal of Sports Medicine · 2014
Abstract: Objectives: To determine and compare the effects of autologous platelet rich plasma (PRP) and hyaluronic acid (HA) for the treatment of osteoarthritis of the knee. Methods: This prospective study included 150 patients affected by severe osteoarthritis of the knee. Gonarthrosis was graded using the Kellgren-Lawrence and Albhack radiographic classification scale. 150 patients were randomized into 2 study groups .In the PRP group (n=55) three intraarticular injection were applied andthe control group (n=55) received 3 intra-articular injections of high molecular weight HA. An unblinded physician performed infiltration once a week for 3 weeks into the knee affected by clinically relevant gonarthrosis...
Anand Kumar, ..., and Ashutosh Kumar
International Journal of Orthopaedics Sciences · 2021
Abstract: Background: Osteoarthritis is the most prevalent type of arthritis, which significantly impacts the patient’s mobility and quality of life. Pharmacological treatments for osteoarthritis, such as corticosteroids, produce an immediate reduction of the patient’s pain as well as an improvement in the patient’s mobility and quality of life, but with a limited long-term efficacy. In this context, platelet-rich plasma (PRP) infiltrations represent a therapeutic tool due to its trophic properties and its ability to control inflammatory processes. Evidence on the effect of platelet-rich plasma (PRP) in treating osteoarthritis (OA) is insufficient. Therefore, the present study compares the effects of a one-time...
P. Rahimzadeh, ..., and S. Faiz
Anesthesiology and Pain Medicine · 2022
Abstract: Context This systematic review and meta-analysis evaluated the effect of the intra-articular injection of platelet-rich plasma (PRP) and oxygen-ozone therapy and provided an evidence-based methodology to treat KOA. Method Databases, including Cochrane Library, PubMed, and EMBASE, were searched. The retrieval period was before 2021. Two reviewers performed the process of screening and data extraction. Mean differences were calculated [95% confidence interval (CI)] with an inverse-variance method and fixed effect model. Meta-analysis was performed using the latest version of STATA version 16. Results A total of 12 studies out of 769 articles were evaluated. The mean difference of visual analog scale...
Hassan Niroomand Sadabad, ..., and H. Dehghan
Electronic Physician · 2016
Abstract: Introduction Knee osteoarthritis is a very common chronic degenerative disease that could impose significant costs to the health system. Although osteoarthritis can affect all joints, knee osteoarthritis is the most common type among adolescents. Non-surgical treatments include corticosteroids injection, hyaluronic acid, and platelet-rich plasma. The aim of this study was to investigate the efficiency of platelet-rich plasma versus hyaluronic acid for the treatment of knee osteoarthritis. Methods Pubmed, Cochran library, Scopus and Ovid databases were investigated to identify related studies from 2000 through August 2015. To study the efficiency, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) outcome using the...
J. Moloo
NEJM Journal Watch · 2015
No summary or abstract available
Huafeng Zhang, ..., and Zhi-jun Li
Drug Design, Development and Therapy · 2018
Abstract: Purpose Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been increasingly used in recent years to treat knee osteoarthritis (OA). However, whether PRP is superior to HA is controversial. Methods We conducted an electronic search of PubMed, Embase, ScienceDirect, and Cochrane library. The pooled data were analyzed using RevMan 5.1. Results Three prospective and ten randomized trials were identified. PRP injections reduced pain more effectively than HA injections in OA of the knee at 6 months (mean difference [MD]=14.18; 95% confidence interval [CI]: 26.12 to 2.23; P=0.02; I2=95%) and 12 months (MD=15.25; 95% CI: 22.17 to 8.32; P<0.01; I2=81%) of...
Yong-Beom Park, ..., and Dong-hyun Lee
The American Journal of Sports Medicine · 2021
Abstract: Background: Although platelet-rich plasma (PRP) has potential as a regenerative treatment for knee osteoarthritis, its efficacy varies. Compositional differences among types of PRP could affect clinical outcomes, but the biological characterization of PRP is lacking. Purpose: To assess the efficacy of intra-articular PRP injection in knee osteoarthritis as compared with hyaluronic acid (HA) injection and to determine whether the clinical efficacy of PRP is associated with its biological characteristics. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 110 patients with symptomatic knee osteoarthritis received a single injection of leukocyte-rich PRP (1 commercial kit) or HA....
Thivagar Murugesan, ..., and Pedapati Ssk Vijaya Guna Surya
Cureus · 2025
Abstract: Background and objective Knee osteoarthritis (OA), a common degenerative joint disease, often leads to chronic pain and disability, particularly in middle-aged individuals. With growing interest in regenerative therapies, platelet-rich plasma (PRP) has emerged as a potential biological treatment due to its anti-inflammatory and reparative properties. This study aimed to evaluate the clinical and functional outcomes following intra-articular PRP injections in patients with early-stage knee OA. Methodology A prospective clinical trial was conducted at a tertiary care center involving 113 patients diagnosed with Kellgren-Lawrence grade 1 or 2 knee osteoarthritis. Each participant received a single intra-articular PRP injection and was followed...
Yong-Beom Park, ..., and Jun-Ho Kim
The American Journal of Sports Medicine · 2025
Abstract: Background: Intra-articular (IA) injections of orthobiologics, such as platelet-rich plasma (PRP) and microfragmented adipose tissue (MFAT), have recently gained attention as treatments for knee osteoarthritis (OA). However, clinical evidence supporting their use remains limited. Purpose: To evaluate the effectiveness and safety of IA injections of PRP and MFAT in patients with knee OA and to compare these 2 treatment modalities. Study Design: Systematic review and meta-analysis; Level of evidence, 2. Methods: A systematic search was conducted in the MEDLINE, Embase, and Cochrane Library databases to identify randomized controlled trials assessing the efficacy and safety of PRP or MFAT injections in...
Jinlong Zhao, ..., and Jun Liu
BMC Musculoskeletal Disorders · 2020
Abstract: Background Studies have shown that the combined application of hyaluronic acid (HA) and platelet-rich plasma (PRP) can repair degenerated cartilage and delay the progression of knee osteoarthritis (KOA). The purpose of this study was to explore the efficacy and safety of the intra-articular injection of PRP combined with HA compared with the intra-articular injection of PRP or HA alone in the treatment of KOA. Methods The PubMed, Cochrane Library, EMBASE and China National Knowledge Infrastructure (CNKI) databases were searched from inception to December 2019. Randomized controlled trials and cohort studies of PRP combined with HA for KOA were included. Two...
Ashwani Sadana Choudhary Abdul
International Journal of Science and Research (IJSR) · 2024
Abstract: : Overview: Articular cartilage deterioration is a prevalent, chronic joint condition known as osteoarthritis (OA) of the knee. It has been shown that intra -articular HA injections are helpful in the treatment of osteoarthritis (OA), since they improve the viscosity of synovial fluid and joint lubrication, restore hyaluronan synthesis, prevent proteoglycan breakdown, and have analgesic and anti - inflammatory properties. For the past ten years, CS have been used to treat OA, and they seem to be reasonably safe. Because CS affect both the mechanisms that contribute to the functioning of inflammatory cytokines and the cytokines themselves, they have...
Zeyad Buahlaika, ..., and Sanad Younes
AlQalam Journal of Medical and Applied Sciences · 2024
Abstract: This study seeks to assess and compare the impact and functional outcomes of platelet-rich plasma and corticosteroid injections in individuals with knee osteoarthritis. In this prospective study, sixty randomly selected patients diagnosed with mild to moderate knee osteoarthritis were included. The patients underwent treatment with either platelet-rich plasma or corticosteroid injection. The assessment of patients was conducted during a follow-up period ranging from six months to one year, utilizing the visual analog scale and the Knee Injury and Osteoarthritis Outcome Score. Written informed consent was obtained from each participant included in the study. This study revealed that patients treated with...
S. Ayub, ..., and Weiya Zhang
Rheumatology · 2021
Abstract: OBJECTIVES To investigate the efficacy and safety of multiple intra-articular corticosteroid (IACS) injections for the treatment of OA. METHODS We conducted electronic searches of several databases for randomized controlled trials (RCTs) and observational studies. Standard mean difference was calculated for efficacy, whereas hazard ratio (HR) was used for adverse effects. Results were combined using the random effects model. Heterogeneity was measured using I2 statistics. RESULTS Six RCTs were included for efficacy assessment. The use of multiple IACS appeared to be better than comparator (standard mean difference for pain -0.47, 95% CI -0.62, 0.31). However, there was considerable heterogeneity (I2 92.6%)...
Raveendhara R. Bannuru, ..., and T. McAlindon
Osteoarthritis and cartilage · 2010
No summary or abstract available
Prant Gupta, ..., and Ajay Bharti
Cureus · 2024
Abstract: Introduction: Knee osteoarthritis (OA) is a prevalent degenerative joint disorder causing pain, stiffness, and reduced function, significantly impacting the quality of life. Current treatments mainly provide symptomatic relief, with limited efficacy in halting disease progression. Platelet-rich plasma (PRP), a biological therapy rich in growth factors, has gained attention as a potential treatment for knee OA due to its regenerative properties. This study evaluates the efficacy of PRP in managing primary knee OA. Methodology: This prospective interventional study included 100 patients diagnosed with primary knee OA, categorized using the Kellgren-Lawrence grading scale. Leukocyte-reduced PRP was prepared using the double-spin method and...
P. Randelli, ..., and A. Menon
Orthopaedic Journal of Sports Medicine · 2021
Abstract: Objectives: Osteoarthritis (OA) of the knee is a debilitating disease whose prevalence has increased across the world with aging population. Platelet-Rich Plasma (PRP) and Hyaluronic Acid (HA) injections appear to be two of the main strategies for conservative treatment of early knee OA. The effectiveness of both treatments, however, is still under debate because contrasting results have been described in the current literature. Some pre-clinical studies evaluated the association of PRP and HA with encouraging results, highlighting the possibility of a synergistic effect between the two compounds and suggesting a possible use through combined intra-articular injections. The aim of this...
Weipeng Zeng, ..., and Caifeng Pei
International Journal of Clinical Practice · 2022
Abstract: Objective. This study systematically evaluated the effect of intraarticular injection of plateletrich plasma (PRP) and mesenchymal stem cells (MSC) on knee osteoarthritis (KOA). Methods. Randomized controlled trials (RCTs) of PRP combined with MSC in the treatment of KOA were collected from PubMed, Cochrane Library, Web of Science, Wiley online library, CNKI, and Wanfang databases from inception to July 30, 2022. Two researchers read and screened the literature to extract the data, respectively. After conducting a riskofbias assessment of included data, RevMan 5.3 software was used for metaanalysis. The Cochrane Handbook riskofbias assessment tool was used to evaluate the included literature....
Medhat Sdeek, ..., and Ahmed Darweash
Acta orthopaedica Belgica · 2021
Abstract: Platelet-rich plasma injections have been proposed as an option for Conservative management of knee Osteoarthritis to provide symptomatic relief and also to delay the need for surgical intervention. Although almost all the current literatures provide some evidence on the benefits of this technique compared with Visco- supplementation, no studies have been performed to compare their Clinical outcomes. The purpose is to compare the Clinical outcomes provided by intra-articular injection of either Platelet rich plasma or Hyaluronic acid to treat knee Osteoarthritis. Study Design: Randomized Controlled Trial 200 Patients with a history of Symptomatic knee Osteo- arthritis (Kellgren-Lawrence grade 2...
Jacques Pretorius, ..., and Sayed Nadeem
Cureus · 2022
Abstract: Introduction Platelet-rich plasma (PRP) intra-articular injections have gained popularity and are suggested to be more effective and longer lasting than corticosteroid or visco-supplementation therapy. There are few studies comparing PRP with corticosteroid injections and none comparing PRP in patients with bilateral knee osteoarthritis with the patient acting as their own control. Methods We performed a double-blind randomized controlled trial including 29 patients (58 knees) with radiologically confirmed mild-to-moderate bilateral knee osteoarthritis. They were randomized to receive an intra-articular PRP injection into one knee and a methylprednisolone injection with a local anesthetic into the contralateral knee. The primary outcome was measured...
Raveendhara R. Bannuru, ..., and T. McAlindon
Seminars in arthritis and rheumatism · 2014
No summary or abstract available
C. Rajasekaran, ..., and Surendher Kumar R
Indian Journal of Orthopaedics Surgery · 2020
Abstract: Background: The effectiveness of platelet-rich plasma (PRP) injections for osteoarthrosis (OA) is still controversial. We investigated the effect of PRP injections in patients with knee osteoarthrosis based on decreasing pain, improving function. Purpose: To assess the outcome of intra-articular platelet-rich plasma (PRP) injections into the knee in patients with early stages of osteoarthrosis (OA). Materials and Methods: This is a prospective study in which 50 knees were followed up for a minimum of 6 months. Two intra articular injections were injected at one month interval. The outcome was assessed using WOMAC and Visual Analogue Scale (VAS) recorded prior to injection...
Ahmed Abu-Awwad, ..., and Gheorghe Szilagyi
Cureus · 2024
Abstract: Background Knee osteoarthritis (KOA), a degenerative joint disease, is a common cause of chronic knee pain and disability in adults. Conservative management options are the first-line approach, but intra-articular injections, such as platelet-rich plasma (PRP) and hyaluronic acid (HA), are considered for advanced cases. This study aims to compare the efficacy of PRP versus HA injections in patients with advanced KOA. Methods A retrospective study was conducted on 145 patients with advanced KOA. Seventy patients received PRP injections, while 75 patients received HA injections. The Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and International...
D. Jevsevar, ..., and D. Cummins
Journal of the American Academy of Orthopaedic Surgeons · 2018
No summary or abstract available
Qinglin Liu, ..., and Hao Chen
PLOS One · 2025
Abstract: Background Knee osteoarthritis (KOA) is a common degenerative joint disease that primarily affects the elderly individuals. Traditional treatments include medications and physical therapy, but recent attention has turned to platelet-rich plasma (PRP) and hyaluronic acid (HA) injection therapies. Objective This meta-analysis aimed to evaluate the efficacy and safety of PRP combined with HA versus PRP alone in the treatment of KOA. Methods We conducted a comprehensive literature search of the PubMed, Embase, and Cochrane Library databases, which included covering publications from their inception to July 2024. Studies comparing PRP+HA with PRP alone were selected. Data on visual analog scale (VAS)...
Society of Orthopaedics and Traumatology
2018
Abstract: BackgroundKnee osteoarthritis (OA) is a disease with a high prevalence in the adult population. Nonsteroidal anti-inflammatory drugs (NSAID) or intra-articular injections [hyaluronic acid (HA) or platelet-rich plasma (PRP)] can provide clinical benefit. Magnetic resonance imaging (MRI) has proven to be useful for the evaluation of cartilage volume and thickness in knee osteoarthritis. The purpose of this study was to evaluate the benefit provided by PRP injection in comparison with hyaluronic acid and NSAID in knee OA patients and to compare the radiographic evolution at the 52-week follow-up.MethodsOne hundred and six patients were enrolled and randomized according to the Spanish Rheumatology...
Alessandro Bensa, ..., and G. Filardo
Expert Opinion on Biological Therapy · 2025
Abstract: ABSTRACT Introduction The aim of this systematic review was to quantify the data available on corticosteroids (CS), hyaluronic acid, (HA), platelet-rich plasma (PRP), and cell-based therapies for knee osteoarthritis (OA) treatment. Methods A literature search was conducted on PubMed, Cochrane, and Web of Science according to the PRISMA guidelines. Inclusion criteria: clinical studies of any level of evidence, written in English, evaluating the intra-articular use of CS, HA, PRP, or cell-based therapies for knee OA treatment. Results The initial search identified 17,415 records. A total of 766 studies from 1959 were included. Of these, 401 were randomized controlled trials (RCTs),...
Diego Ivan Diaz Haaz and Oswaldo Rizo Castro
Cureus · 2025
Abstract: Osteoarthritis (OA) is a prevalent condition that significantly impacts the quality of life due to pain and associated disability. Platelet-rich plasma (PRP) injections have emerged as a promising alternative treatment, though their efficacy and safety remain debatable. This systematic review aims to evaluate the efficacy and safety of PRP injections in patients with knee OA by analyzing randomized clinical trials (RCTs). A comprehensive search was conducted across PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and the Virtual Health Library (VHL) for studies published from 2019 to 2024, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines....
Samer Redah
Medical Journal of Babylon · 2022
Abstract: Background: Osteoarthritis (OA) is a leading cause of disability and doubles the number of visits to primary care practitioners for those with the condition in comparison to those without. OA affects the knee more often than any other joint, Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. Objective: the aim of this prospective study is to demonstrate the effectiveness of prp injection in patients with OA of the knee. Materials and Methods: 60 patients with 74 knees affected by variable grades...
Soad Elsawy, ..., and M. Ahmed
Egyptian Rheumatology and Rehabilitation · 2017
Abstract: Objective Osteoarthritis (OA) is a chronic degenerative joint disease characterized by pain and progressive functional limitation. Although both corticosteroid and hyaluronic acid (HA) injections are widely used to palliate the symptoms of knee OA, few researches involving a comparison of two interventions have been conducted. The objective of the study was to compare the efficacy and safety of HA to corticosteroid injections for the treatment of knee OA. Patients and methods We enrolled 60 patients with knee OA who were randomized to receive intra-articular injection of either HA or the corticosteroid. The therapy was followed for 6 months. The patients...
Pan Wang, ..., and Zhengjiang Li
Medicine · 2021
Abstract: Abstract Background: Two published meta-analyses have investigated the effects of the number of injections of platelet rich plasma (PRP) on clinical outcomes in knee osteoarthritis patients, however conflicting findings were generated. Methods: We will systematically search PubMed, Embase, and China National Knowledgement Infrastructure (CNKI) to capture additional eligible studies. After screening citations, extracting essential data, assessing the risk of bias, we will use RevMan software and Open BUGS to perform head-to-head and network meta-analysis of pain alleviation and improvement of joint functionality, respectively. Discussion: Knee joint osteoarthritis (KOA) is the main cause of joint degeneration in elderly, which seriously reduces...
Gian Ivander, ..., and Yovita Anggono
Open Access Macedonian Journal of Medical Sciences · 2024
Abstract: Abstract AIM: This study aimed to perform a systematic review (SR) of SR to elucidate prior findings regarding favorable outcomes between platelet-rich plasma (PRP) and hyaluronic acid (HA) injections for early knee osteoarthritis (KOA). MATERIALS AND METHODS: We conducted a thorough literature search adhering to the Preferred Reporting Items for SR and Meta-analyses only for SRs from PubMed, ScienceDirect, and Google Scholar from 2020 to 2023. The inclusion and exclusion criteria were determined using the population, intervention, comparison, outcome, and study design model. A measurement tool to assess SR-2 was used to grade the included SRs. Two researchers independently searched,...
B. Cole, ..., and L. Fortier
The American Journal of Sports Medicine · 2017
No summary or abstract available
C. Pojala, ..., and Lorena Dima
Clinics and Practice · 2024
Abstract: Background: Knee osteoarthritis (KOA) is a common degenerative and progressive joint disorder that negatively influences patients’ quality of life. Intra-articular therapies, such as hyaluronic acid (HA) and platelet-rich plasma (PRP), have garnered attention for their potential to manage osteoarthritis OA symptoms effectively. This systematic review aims to identify the effectiveness and safety of HA and PRP treatment modalities in treating KOA. Methods: A literature search was conducted across MEDLINE (PubMed), Web of Science Core Collection, and Science Direct Collection Elsevier. Twenty-three randomized controlled trials, cohort studies, and observational studies were included in the review. The selection criteria focused on studies...
Sandeep Patel, ..., and M. Dhillon
Orthopaedic Journal of Sports Medicine · 2024
Abstract: Background: Confusion persists regarding the ideal dosage of platelet-rich plasma (PRP) injection for knee osteoarthritis (OA). Purpose/Hypothesis: The purpose of the study was to compare the efficacy of 2 different single-injection PRP dosages in patients with early knee OA—a conventional 4 mL dose and a superdose of 8 mL. It was hypothesized that 8 mL of PRP would be superior to 4 mL of PRP in this patient population. Study Design: Randomized clinical trial; Level of evidence, 1. Methods: Patients with early knee OA (Kellgren-Lawrence grades 1 and 2) who met the inclusion criteria were randomly divided into 2 groups:...
A. Ismaiel
Journal of Medicine in Scientific Research · 2018
Abstract: Objective The objective of this study was to compare intra-articular injections (IAIs) of platelet-rich plasma (PRP) and corticosteroid injections in reducing pain and studying which has a more effective and lasting functional improvement. Patients and methods A total of 60 patients with chronic knee osteoarthritis (Kellgren–Lawrence grades 3 and 4) were enrolled in this study. Patients were randomized to treatment either with a single leukocyte-rich PRP or corticosteroid IAIs. Patients were assessed by visual analog scale, and Knee injury and Osteoarthritis Outcome Score at 1, 3, and 6 months after treatment. Results Our results showed improvement in all variables in...
Adel H Hegaze, ..., and M. Hegazy
Cureus · 2021
Abstract: Background Osteoarthritis (OA) is a degenerative disease commonly affecting the knee joints. It affects patients socially, psychologically and economically and rates of the disease have been increasing due to obesity and old age. Regardless of choosing a medically conservative approach, it is a challenge in the long term to provide OA patients efficient treatment with minimal side effects and long-term efficiency. Platelet-rich plasma (PRP) is a convenient, low-cost and affordable treatment technique used in treating knee OA with encouraging efficient and safe outcomes. In this study we will investigate the effect of PRP on knee OA. Methods This is a...
João Paulo Rodrigues Pacheco, ..., and João Paulo Ramos de Morais
MedNEXT Journal of Medical and Health Sciences · 2025
Abstract: Introduction: Bone diseases comprise a large group of common diseases, including fractures, osteoporosis, and osteoarthritis that affect a large number of individuals. Knee osteoarthritis (KOA) refers to a chronic joint disease characterized by degenerative lesions of the knee cartilage, causing pain, swelling, dyskinesia, and other symptoms of the knee joint. According to the World Health Organization (WHO), KOA has an incidence of approximately 10-15%, with the elderly population accounting for 95%. Objective: This was to conduct a systematic review to present state of the art, through randomized clinical trials and meta-analyses, of the treatment of knee osteoarthritis using platelet-rich plasma...
S. A. Raeissadat, ..., and M. Darvish
Annals of the Rheumatic Diseases · 2020
Abstract: Background: Knee osteoarthritis (OA) as a common progressive degenerative condition is one of the most important leading causes of disability and relative dependence. Worldwide prevalence of symptomatic knee OA has estimated 3.8%. It affects more than 20% of over 45-year-old population. Among the minimally invasive methods recommended for knee OA management is intra-articular injections for which a large array of products have been used. Despite all the existing options, there is still no general consensus on the choice and priority of the best intra-articular injection in knee osteoarthritis. Objectives: Our study compare the short and long-term efficacy of the intra...
B. Bara, ..., and A. Zekovic
Annals of the Rheumatic Diseases · 2019
Abstract: Background: Osteoarthritis pathogenesis is a complex process associated with decreased ability to regenerate cartilage mainly due to lack of physiological vascularization. One of the most commonly affected joints is the knee. Objectives: The aim of this study was to compare the efficacy of intra-articular (IA) injections of platelet rich plasma (PRP) combined with hyaluronic acid (HA) prepared with the Cellular Matrix device versus IA injections with two different types of hyaluronic acid for treatment of knee osteoarthritis. Methods: This is a prospective, randomized, double-blind, controlled study on 53 patients (90 knees) suffering from knee osteoarthritis, divided in 3 groups. The...
A. Gazendam, ..., and M. Bhandari
British Journal of Sports Medicine · 2020
Abstract: Objective Intra-articular (IA) injections represent a commonly used modality in the treatment of hip osteoarthritis (OA). Commonly used injections include corticosteroids (CCS), hyaluronic acid (HA) and platelet-rich plasma (PRP). A network meta-analysis allows for comparison among more than two treatment arms and uses both direct and indirect comparisons between interventions. The objective of this network meta-analysis is to compare the efficacy of the various IA injectable treatments in treating hip OA at up to 6 months of follow-up. Design This is a systematic review and network meta-analysis. Bayesian random-effects model was performed to assess the direct and indirect comparisons of...
Yiying Mai, ..., and Li Jiang
BMJ Open · 2023
Abstract: Introduction 54% of patients with moderate-to-severe knee osteoarthritis (KOA) still reported persistent pain and functional loss after conservative treatment according to guidelines. As an emerging treatment, platelet-rich plasma (PRP) has been proven to significantly relieve pain and improve activity function in patients with mild-to-moderate KOA, either used alone or in combination with hyaluronic acid (HA). However, it is still unclear of its efficacy in moderate-to-severe KOA. This study aims to evaluate the clinical efficacy of PRP and the combination therapy of PRP and HA in patients with moderate-to-severe KOA and to explore the potential synergistic effect of PRP and HA....
R. Ossendorff, ..., and F. Schildberg
Deutsches Arzteblatt international · 2023
Abstract: BACKGROUND Osteoarthritis is a degenerative joint disease that is becoming increasingly common as the population ages. Conservative treatment for hip or knee osteoarthritis has been limited to pain control. Intra-articular injections for targeted local treatment have been widely used in clinical practice for many years. METHODS This review is based on publications retrieved by a selective literature search, including recent meta-analyses, systematic reviews, randomized controlled trials (RCTs), and current guidelines. RESULTS In Germany, the 12-month prevalence of osteoarthritis in adults is 17.9%. Conservative treatments are intended to alleviate symptoms and do not affect the progression of the disease. Glucocorticoids can...
Ambika Singh, ..., and Khavir A Sharieff
Cureus · 2024
Abstract: Knee osteoarthritis (KOA) is a healthcare burden affecting over 595 million people worldwide. Recently, intra-articular platelet-rich plasma (PRP) injections from the patient's blood have shown promise in slowing KOA progression due to platelets’ regenerative properties. This study aimed to evaluate the optimal dosing and schedule for PRP therapy in managing mild to moderate KOA. A systematic search was conducted across Embase, Ovid Medline, Web of Science, Cochrane Central, and CINAHL using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify articles published from August 2015 to March 2024. Keywords included “platelet rich plasma,” “knee osteoarthritis,” and...
Ismail A. Yassin, ..., and Mahmoud A. M. Beltagy
Al-Azhar Assiut Medical Journal · 2020
Abstract: Background Osteoarthritis (OA) is a degenerative joint disease of multifactorial etiology and affects synovial joints. The risk of developing OA substantially increases with each decade after the age of 45 years. It is characterized by progressive deterioration and loss of articular cartilage with structural and functional changes in the entire joint, including the synovium, periarticular ligaments, and subchondral bone. Objective To assess the clinical effects of intra-articular injection of platelet-rich plasma (PRP) into the knee joint with mild to moderate OA regarding pain, quality of life, and return to activity. Patients and methods The study included 30 patients in the...
G. V. van Buul, ..., and G. V. van Osch
The American Journal of Sports Medicine · 2011
No summary or abstract available
Longxiang Shen, ..., and Changqing Zhang
Journal of Orthopaedic Surgery and Research · 2017
Abstract: BackgroundQuite a few randomized controlled trials (RCTs) investigating the efficacy of platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently published. Therefore, an updated systematic review was performed to evaluate the temporal effect of PRP on knee pain and physical function.MethodsPubmed, Embase, Cochrane library, and Scopus were searched for human RCTs comparing the efficacy and/or safety of PRP infiltration with other intra-articular injections. A descriptive summary and quality assessment were performed for all the studies finally included for analysis. For studies reporting outcomes concerning Western Ontario and McMaster Universities Arthritis Index (WOMAC) or adverse events, a random-effects...
Sagolsem Adarsh Singh, ..., and Yumnam Ningthemba Singh
International Journal of Research and Review · 2024
Abstract: Background: Osteoarthritis is a common and disabling condition that represents a substantial and increasing health burden with notable implications for the individuals affected, health-care systems, and wider socioeconomic costs. Despite significant advances in science and medicine, there is no cure for osteoarthritis. Numerous treatment options have been used for management of osteoarthritis including pharmacological and invasive techniques. Regenerative therapy like Platelet rich plasma and Prolotherapy are being extensively studied due to their ability to regenerate and repair damaged tissues. Objectives: To evaluate the effectiveness of platelet rich plasma injection in comparison with dextrose prolotherapy on improving pain and function in...
A. Hegazy, ..., and A. Selim
The Journal of the International Society of Physical and Rehabilitation Medicine · 2019
Abstract: Background: Osteoarthritis (OA) of the knee is a significant cause of disability. The current conservative treatment options include physiotherapy, analgesia, intra-articular injection of platelet-rich plasma (PRP), hyaluronic acid, or corticosteroids. Regarding PRP, some meta-analyses studies have been reported. However, these studies focused on the effectiveness of intra-articular PRP when compared to other controls, and none thoroughly investigated the anchored-based effectiveness concerning the minimal clinically important difference (MCID). Objective: We, therefore, conducted this work to address this apparent knowledge gap and to provide objective data that could be used by decision-makers. Methods: Electronic databases were searched to identify relevant publications. We...
Hung-Ya Huang, ..., and Shu-Fen Sun
BMC Musculoskeletal Disorders · 2022
Abstract: Background Intraarticular plasma-rich platelet (PRP) and hyaluronic acid (HA) have each been shown to be effective for treating knee osteoarthritis (OA). Evidence supporting the combination therapy is controversial. This study aimed to investigate the efficacy of a single intraarticular PRP injection combined with different HAs in patients with knee OA. Methods In this prospective randomized-controlled trial, 99 patients with Kellgren-Lawrence grade 2 knee OA with average knee pain e 30 mm on a 0-100 mm pain visual analog scale (VAS) were randomized into two groups. The PRP + Artz group received a single intraarticular HA (Artz, 2.5 ml, 10 mg/ml)...
Çalar Karaba_ and E. A. Tezca
nNorthern Clinics of Istanbul · 2025
Abstract: OBJECTIVE Osteoarthritis (OA) is a prevalent and disabling joint condition that affects millions worldwide, particularly in the knee joint, and it presents limited therapeutic options. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have emerged as promising intra-articular treatments. This study aimed to compare the effects of single-dose PRP and HA on pain, functionality, and stiffness in patients with knee OA over a 12-week follow-up period. METHODS A retrospective analysis was conducted on 64 patients who underwent single-dose intra-articular HA or PRP treatment for knee OA between December 2021 and June 2022. Pain and functional outcomes were assessed using the Visual...
D. Malanin, ..., and K. V. Baidova
Orthopaedic Genius · 2017
Abstract: Introduction There have not been highly effective and equally safe tools available to relieve pain and improve joint function in patients suffering from osteoarthritis. Purpose Explore the efficacy of intra-articular application of autologous platelet-rich plasma (PRP) in the treatment of patients affected by grade 2 osteoarthritis of the knee. Material and methods The study was designed as a single-arm prospective randomized trial. A total of 60 patients with grade 2 osteoarthritis according to the J. Kellgren and J. Lawrence grading scale (1957) were enrolled in the study. Patients were divided into two clinical groups, with 30 subjects in each group....
Jennifer E Woodell-May, ..., and J. Hoeppner
Journal of Orthopaedic Research · 2011
No summary or abstract available
Y. Di, ..., and Yizhong Ren
Arthritis Research & Therapy · 2018
Abstract: BackgroundIn this study, we evaluated whether platelet-rich plasma (PRP) is superior to hyaluronic acid (HA) in the treatment of knee osteoarthritis.Meth-odsThe Cochrane Central Register of Controlled Trials, PubMed, and Embase databases were searched for English-language, human in vivo studies on the treatment of symptomatic knee osteoarthritis with intra-articular PRP compared with HA. The following keywords were used for the search: “platelet-rich plasma,” “PRP,” “platelet-rich fibrin,” “PRF,” “platelet,” “plasma,” “arthritis,” “osteoarthritis,” “gonarthrosis,” and “degeneration.”ResultsSeven articles reporting 908 patients and 908 knees were analyzed, including 44% men and 56% women with a mean age of 59.8 years. All studies met the minimal...
Qirong Ma, ..., and Jianfeng Xu
Evidence-based Complementary and Alternative Medicine : eCAM · 2022
Abstract: Knee osteoarthritis is a common chronic degenerative joint disease in middle-aged and elderly people. Intra-articular injection for the treatment of knee osteoarthritis is a regularly utilized nonsurgical treatment in modern medicine. Hyaluronic acid (HA) and platelet-rich plasma (PRP) are two frequently employed intra-articular devices. Hyaluronic acid (HA) is an accepted nonsurgical treatment for symptomatic KOA, and platelet-rich plasma is a popular option in the treatment of KOA in recent years. The purpose of this research is to compare the efficacy and safety of intra-articular injection of platelet-rich plasma (PRP) versus hyaluronic acid (HA) on the pain score scale, knee function,...
David H Pratt and T. Thrasher
Evidence-Based Practice · 2020
Abstract: and 12 months (five trials, N5450; MD –1.8; 95% CI, –2.5 to –1.0; I589%). Study limitations included inconsistencies in plasma preparations (ie, leukocyterich or leukocyte-poor) and differences in quantity and interval of injections. Significant statistical heterogeneity was observed in the outcomes, and several of the individual studies were underpowered. A 2018 meta-analysis of three prospective cohort studies and 10 RCTs (N51,524) compared intraarticular PRP injections versus hyaluronic acid injections for pain reduction in early knee osteoarthritis. Nine of 13 studies were included in the above 2019 meta-analysis; however, this review included four unique studies because of a search strategy that...
M. S. Hamed
The Egyptian Journal of Hospital Medicine · 2022
Abstract: Background: Osteoarthritis (OA) is one of the crucial musculoskeletal disorders that are characterized by the imbalanced homeostasis and destruction of the articular cartilage. Objective: This study aimed to evaluate the effect of platelet-rich plasma (PRP) in treatment of knee osteoarthritis. Patients and Methods: This interventional study was carried out on 20 patients who were suffering from mild to moderate primary osteoarthritis of knee joint during the period from May 2012 to March 2013. They were diagnosed clinically, and by plain x- ray and Doppler musculoskeletal ultrasound. Results: There were 5 patients (25%) experienced slight pain at the site of injection...
Review Odi Bayu Dharma Perkasa Gede and Stedi Adnyana Christian. The International Journal of Medical Science and Health Research, 2024. 0 citations. Abstract: Background: Knee osteoarthritis (KOA) is an active, heterogeneous, and low-grade inflammatory condition leading to functional disability and pain. The aim: The aim of this study to show about the effect of intraosseus infiltration of platelet rich plasma for knee osteorthritis. Methods: By the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. Result: Eight publications were found to be directly related to our ongoing systematic examination after a rigorous three-level screening approach. Subsequently, a comprehensive analysis of the complete text was conducted, and additional scrutiny was...
S. A. Raeissadat, ..., and K. Azma. Clinical Medicine Insights
Arthritis and Musculoskeletal Disorders · 2015
Abstract: Introduction Knee osteoarthritis (OA) is the most common articular disease. Different methods are used to alleviate the symptoms of patients with knee OA, including analgesics, physical therapy, exercise prescription, and intra-articular injections (glucocorticoids, hyaluronic acid [HA], etc). New studies have focused on modern therapeutic methods that stimulate cartilage healing process and improve the damage, including the use of platelet-rich plasma (PRP) as a complex of growth factors. Due to the high incidence of OA and its consequences, we decided to study the long-term effect of intraarticular injection of PRP and HA on clinical outcome and quality of life of patients...
B. Cole, ..., and Brian Forsythe
Orthopaedic Journal of Sports Medicine · 2015
Abstract: Objectives: Osteoarthritis (OA) is a debilitating disease that, in some form, affects up to 47 million Americans each year and is estimated to affect 67 million by 2030. Hyaluronic acid (HA) is currently utilized as an intra-articular injection for treatment of patients with knee OA. A movement in biochemical research has emerged that focuses on analysis of catabolic and anabolic growth factors of the joint. It is proposed that platelet-rich plasma (PRP) is a biologic alternative to HA that may alter the intra-articular biologic milieu to mitigate the symptoms of OA. The purpose of this double-blind prospective randomized clinical trial...
Yanhong Han, ..., and Jun Liu
Medicine · 2018
Abstract: Background: Knee osteoarthritis (KOA) is a progressive joint disease involving intraarticular and periarticular structures. In recent years, there has been increasing interest in the use of autologous growth factors, such as intraarticular injections of platelet-rich plasma (PRP), to treat KOA. It is necessary to update the research and reevaluate the efficacy and safety of PRP to provide up-to-date evidence for KOA management. Therefore, we provide a protocol for a systematic review of PRP for KOA. Methods: The aim of this study was to retrieve papers on the topic of PRP treatment for KOA in electronic databases including PubMed, Embase, and...
Esraa M Bastawy, ..., and Nermin H. El-Gharbawy
The Egyptian journal of immunology · 2024
Abstract: Primary knee osteoarthritis (KOA) is a persistent condition marked by the gradual deterioration of the joint and cartilage loss on its surfaces. Recently, platelet-rich plasma (PRP) was considered a biological intervention that alleviates symptoms and restricts the advancement of primary KOA in patients. This study aimed to evaluate the effect of intra-articular PRP injections on synovial repair through cytokine assays in 20 patients with primary KOA. Patients received two intra-articular PRP injections, spaced one month apart. The role of PRP was assessed by measuring Transforming growth factor beta (TGF-²)a nd interleukin-17 (IL-17) levels in synovial fluid before and after the...
J. Neyeloff, ..., and L. Moreira
BMC Research Notes · 2012
Abstract: Meta-analyses are necessary to synthesize data obtained from primary research, and in many situations reviews of observational studies are the only available alternative. General purpose statistical packages can meta-analyze data, but usually require external macros or coding. Commercial specialist software is available, but may be expensive and focused in a particular type of primary data. Most available softwares have limitations in dealing with descriptive data, and the graphical display of summary statistics such as incidence and prevalence is unsatisfactory. Analyses can be conducted using Microsoft Excel, but there was no previous guide available. We constructed a step-by-step guide to perform...
E. Thienpont
The New England journal of medicine · 2015
No summary or abstract available
S. Suleiman, ..., and Mahmoud El-Sorogy
Menoufia Medical Journal · 2019
Abstract: Objectives The aim of this study was to determine the effect of local injection of platelet-rich plasma (PRP) in patients with mild and moderate knee osteoarthritis (OA) and its effect on pain in comparison to corticosteroid injection. Background OA is one of the most prevalent chronic musculoskeletal diseases worldwide. The use of PRP appeared in the last years for the management of symptoms of knee OA. Patients and methods This study included 50 patients with knee OA. Our patients were divided to two groups: a group of 25 patients who were injected intra-articularly with about 3–4 ml of PRP and...
D. Szwedowski, ..., and S. Jeka
International Journal of Molecular Sciences · 2021
Abstract: Knee osteoarthritis (KOA) represents a clinical challenge due to poor potential for spontaneous healing of cartilage lesions. Several treatment options are available for KOA, including oral nonsteroidal anti-inflammatory drugs, physical therapy, braces, activity modification, and finally operative treatment. Intra-articular (IA) injections are usually used when the non-operative treatment is not effective, and when the surgery is not yet indicated. More and more studies suggesting that IA injections are as or even more efficient and safe than NSAIDs. Recently, research to improve intra-articular homeostasis has focused on biologic adjuncts, such as platelet-rich plasma (PRP). The catabolic and inflammatory intra-articular processes that...
E. Ayhan, ..., and Is1k Akgun
World journal of orthopedics · 2014
Abstract: Osteoarthritis (OA) is a complex "whole joint" disease pursued by inflammatory mediators, rather than purely a process of "wear and tear". Besides cartilage degradation, synovitis, subchondral bone remodeling, degeneration of ligaments and menisci, and hypertrophy of the joint capsule take parts in the pathogenesis. Pain is the hallmark symptom of OA, but the extent to which structural pathology in OA contributes to the pain experience is still not well known. For the knee OA, intraarticular (IA) injection (corticosteroids, viscosupplements, blood-derived products) is preferred as the last nonoperative modality, if the other conservative treatment modalities are ineffective. IA corticosteroid injections provide...
W. Glinkowski, ..., and Dariusz Zladowsk
iJournal of Clinical Medicine · 2025
Abstract: Background: Platelet-rich plasma (PRP) is increasingly utilized for managing knee osteoarthritis (KOA), yet its clinical value remains debated due to the variability in preparation protocols and outcome measures. Methods: This narrative review synthesizes current evidence from 40 high-quality studies published between 2013 and March 2025, including randomized controlled trials, systematic reviews, and meta-analyses. The biological mechanisms, clinical effectiveness, safety, and implementation challenges of PRP therapy in KOA are examined. Results: PRP injections—particularly leukocyte-poor PRP—demonstrate superior pain relief and functional improvement compared to hyaluronic acid and corticosteroids, especially in patients with mild to moderate KOA (Kellgren–Lawrence grades I–III). However, heterogeneity in...
F. Wang and Xijing He
Experimental and Therapeutic Medicine · 2014
Abstract: The aim of the present study was to evaluate the therapeutic effect of intra-articular hyaluronic acid (HA) in comparison to corticosteroids (CS) for knee osteoarthritis (OA). The data sources included PubMed, EMBASE, The Cochrane Central Register of Controlled Trials and hand searched reviews. Randomized controlled trials that reported the effects of intra-articular HA and CS in the treatment of knee OA were selected based on specific inclusion criteria. A meta-analysis was performed for the visual analog scale (VAS), Lequesne index, Knee Society Clinical Rating System (KSS), maximum flexion and adverse events of knee OA. Sensitivity analysis was also conducted to...
Michael J. DeRogatis, ..., and Michael A Mont
Annals of translational medicine · 2019
Abstract: Background Knee osteoarthritis (OA) is a prevalent and debilitating condition for which a wide range of non-surgical treatment options are available. Although there is plethora of literature investigating their safety and efficacy, for many treatment modalities, a consensus has not yet been reached concerning efficacy. Therefore, it is essential for practitioners to understand the risks and benefits of the available treatments for the successful management of knee OA. This study explored the efficacy of non-surgical treatment options for knee OA including: (I) non-steroidal anti-inflammatory drugs (NSAIDs); (II) weight loss; (III) intra-articular injections; (IV) physical therapy; and (V) bracing. Methods A...
Jaydeep Dhillon, ..., and Matthew Kraeutler
Open Access Journal of Sports Medicine · 2025
Abstract: Abstract Knee osteoarthritis (OA) is a common degenerative joint disease affecting approximately 22% of adults over the age of 40 and is a major contributor to pain and disability worldwide. Platelet-rich plasma (PRP) has gained attention as a biologic treatment for this pathology due to its potential in modulating inflammation. This narrative review evaluates the current evidence on PRP for knee OA, comparing its efficacy to hyaluronic acid (HA), corticosteroids, and bone marrow aspirate concentrate (BMAC). High-quality studies consistently demonstrate that PRP provides superior pain relief and functional improvement compared to HA and corticosteroids and offers comparable results to BMAC....
Pu Chen, ..., and Qingfu Wang
Journal of Orthopaedic Surgery and Research · 2019
Abstract: ObjectiveThe purpose of this study was (1) to perform a summary of meta-analyses comparing platelet-rich plasma (PRP) injection with hyaluronic acid (HA) and placebo injection for KOA patients, (2) to determine which meta-analysis provides the best available evidence to making proposals for the use of PRP in the treatment of KOA patients, and (3) to highlight gaps in the literature that require future investigation.Material and methodsPubMed, EMBASE, and Cochrane databases search were performed for meta-analyses which compared PRP injection with HA or placebo. Clinical outcomes and adverse events were extracted from these meta-analyses. Meta-analysis quality was assessed using the Quality...
R. Prill, ..., and J. Karlsson
Knee Surgery, Sports Traumatology, Arthroscopy · 2023
No summary or abstract available
A. Migliore and M. Granata
Clinical Interventions in Aging · 2008
Abstract: Osteoarthritis is one of the leading causes of disability in the elderly. The changes in the lubricating properties of synovial fluid lead to significant pain and loss of function. More than ten years have passed from the first studies. Up till now many authors have supported intra-articular hyaluronan (HA) therapy as not only a symptom-modifying therapy but also a treatment which may significantly decrease the rate of deterioration of joint structure. In this review we report data relative to knee and hip treatment. The ongoing studies continue to further our understanding of the fundamental mechanisms that likely underlie the therapeutic...
Angelo Boffa, ..., and G. Filardo
Knee Surgery, Sports Traumatology, Arthroscopy · 2023
Abstract: Aim of this systematic review was to determine if bone marrow-derived cell-based injectable therapies induce disease-modifying effects in joints affected by osteoarthritis (OA) in animal models. A systematic review was performed on three electronic databases (PubMed, Web of Science, Embase) according to PRISMA guidelines. A synthesis of the results was performed investigating disease-modifying effects in preclinical animal studies comparing injectable bone marrow-derived products with OA controls or other products, different formulations or injection intervals, and the combination with other products. The risk of bias was assessed according to the SYRCLE’s tool. Fifty-three studies were included (1819 animals) with an increasing...
Nayana Joshi Jubert, ..., and A. Navarro
Orthopaedic Journal of Sports Medicine · 2017
Abstract: Background: Intra-articular injections of platelet-rich plasma (PRP) to treat symptoms of knee osteoarthritis (OA) have been successfully used in young patients and in the early stages of disease. No previous studies have analyzed outcomes of PRP injections during the late stages. Hypothesis: PRP reduces pain and leads to a more effective and lasting functional recovery than corticosteroid with local anesthetic. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 75 patients with symptomatic knee OA (Kellgren-Lawrence grade 3 to 4) were enrolled in this study between August 2013 and July 2014. Patients were randomized to treatment...
Mrinal Joshi and Mahima Agrawal
Indian Journal of Physical Medicine and Rehabilitation · 2019
Abstract: A bstrAct Objectives: To demonstrate the effect of autologous platelet-rich plasma (PRP) injections on pain and functional activities in patients with osteoarthritis (OA) knee. Study design: Prospective interventional study. Materials and methods: A detailed demographic data were collected, and each patient was examined clinically and radiographically. Complete blood counts, prothrombin time (PT)/international normalized ratio (INR), and X-rays of bilateral knees were taken. Radiological grading was done on Kellgren–Lawrence (KL grading) OA scale. Each individual was explained and informed consent was taken before the procedure. Three injections of PRP were given at an interval of 2 weeks. Detailed clinical examination was...
R. Prill, ..., and R. Becker
Knee Surgery, Sports Traumatology, Arthroscopy · 2021
No summary or abstract available
J. Higgins
Journal not specified · 2011
No summary or abstract available
Association of North America and the International Arthroscopy Association
2019
No summary or abstract available
of North America and the International Arthroscopy Association
2017
No summary or abstract available
Sandeep Patel, ..., and Ashish Jain
The American Journal of Sports Medicine · 2013
No summary or abstract available
C. Lisi, ..., and G. Di Natali
Clinical Rehabilitation · 2018
No summary or abstract available
Alireza Teymouri, ..., and Aref Nasiri
BMC Musculoskeletal Disorders · 2025
Abstract: Knee osteoarthritis (OA) is a debilitating condition that manifests as knee pain and dysfunction. Clinicians prefer non-surgical options such as intra-articular injections for mild to moderate disease. Dextrose prolotherapy (DPTx) has been shown to have a beneficial effect on knee OA in the long-term. In this randomized controlled trial (RCT), we aimed to compare DPTx with intra-articular normal saline injection (IA-NS) to treat knee OA in terms of effectiveness and patient-reported outcomes. The study was a double-blind RCT with an allocation ratio of 1:1. We used block randomization to assign patients to each treatment arm. Patients with a visual analog...
Y. Saita, ..., and M. Ishijima
Regenerative Therapy · 2025
No summary or abstract available
J. F. Lana, ..., and W. Belangero
Journal of Stem Cells & Regenerative Medicine · 2016
Abstract: Objective: This study aims at evaluating the clinical effects of Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) as individual treatments for mild to moderate Osteoarthritis (OA) and it also examines the potential synergistic effects of PRP in combination with HA. Research continues to emerge examining the potential therapeutic efficacy of HA and PRP as autologous injectable treatments for joint arthritis. However, there is a paucity of research investigating the effects of combining HA and PRP on pain and functional status in patients with OA. Design: In this multi-center, randomized, controlled, double blind, prospective trial, 105 patients with mild to...
Hamada S Ahmad, ..., and I. Shady
International Journal of Rheumatic Diseases · 2018
No summary or abstract available
P. Smith
The American Journal of Sports Medicine · 2016
No summary or abstract available
M. Santiago, ..., and Rosana Cipolotti
Frontiers in Bioengineering and Biotechnology · 2025
Abstract: Background The use of intra-articular orthobiologics in hip osteoarthritis (HOA) has been presented as a therapeutic option and to postpone arthroplasty. There is little scientific evidence on the clinical application of platelet-rich plasma (PRP) associated with hyaluronic acid as dual therapy. Thus, the aim of our systematic review is to compare the clinical improvement with the use of PRP with versus without hyaluronic acid (HA) in hip osteoarthritis. Methods We systematically searched Cochrane, PubMed, and Embase databases for studies evaluating patients with HOA who received PRP with vs. without HA. Pain and functional score were collected and pooled at 3-,...
T. M. Duymu_, ..., and F. N. Kesikta
K_nee Surgery, Sports Traumatology, Arthroscopy · 2017
No summary or abstract available
G. Filardo, ..., and E. Kon
The American Journal of Sports Medicine · 2015
No summary or abstract available
B. Forogh, ..., and S. Sajadi
The Journal of sports medicine and physical fitness · 2016
No summary or abstract available
A. Di Martino, ..., and G. Filardo
The American Journal of Sports Medicine · 2018
Abstract: Background: Platelet-rich plasma (PRP) injections have been proposed as a new conservative option for knee degeneration to provide symptomatic relief and delay surgical intervention. Although the current literature provides some evidence on the benefits of this technique compared with viscosupplementation, no studies have been performed to compare their long-term effects. Purpose: To compare the long-term clinical outcomes provided by intra-articular injections of either PRP or hyaluronic acid (HA) to treat knee degenerative disease. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Patients with a history of chronic symptomatic knee degenerative changes and osteoarthritis (Kellgren-Lawrence grade 0-3) were enrolled:...
S. A. Raeissadat, ..., and Omid Gharooi Ahangar. Clinical Medicine Insights
Arthritis and Musculoskeletal Disorders · 2017
Abstract: Background and objectives: Knee osteoarthritis is the most common joint disease. We aimed to compare the efficacy and safety of intra-articular injection of a newly developed plasma rich in growth factor (PRGF) versus hyaluronic acid (HA) on pain and function of patients with knee osteoarthritis. Methods: In this single-blinded randomized clinical trial, patients with symptomatic osteoarthritis of knee were assigned to receive 2 intra-articular injections of our newly developed PRGF in 3 weeks or 3 weekly injections of HA. Our primary outcome was the mean change from baseline until 2 and 6 months post intervention in scores of visual analog...
Raveendhara R. Bannuru, ..., and T. McAlindon
Osteoarthritis and cartilage · 2019
No summary or abstract available
T. McAlindon, ..., and R. Ward
JAMA · 2017
No summary or abstract available
E. Lewis, ..., and K. Ogden
The bone & joint journal · 2022
No summary or abstract available
Mario Simental-Mendía, ..., and C. Acosta-Olivo
Drugs & Aging · 2023
No summary or abstract available
W. Glinkowski and WiesBaw Tomaszewsk
iJournal of Clinical Medicine · 2025
Abstract: Objective: to evaluate the efficacy, safety, and cost-effectiveness of intra-articular hyaluronic acid (IAHA) in treating osteoarthritis (OA), considering innovations in formulations, comparative outcomes, and variability in guidelines. This review aims to synthesize evidence supporting the role of IAHA in multimodal treatment strategies. Materials and Methods: A general, narrative, umbrella review of systematic reviews and meta-analyses was conducted. Clinical practice recommendations and guidelines for IAHA use were also reviewed and evaluated. A comprehensive search was conducted across the main medical data sources. Inclusion criteria focused on studies evaluating the efficacy, safety, and impact of IAHA. Key outcomes included pain reduction (e.g.,...
Martin Lamontagne, ..., and Naomie Maltais
Journal de Traumatologie du Sport · 2025
No summary or abstract available
A. Shtanova, ..., and E. A. Volokitina
Ural Medical Journal · 2025
Abstract: Introduction. The primary local treatments for knee osteoarthritis (OAKS) include hyaluronic acid (HA) and platelet-rich plasma (PRP) injections. The visual analogue pain scale (VAS) is often used to assess their effectiveness. Ongoing debate persists regarding which method provides the most sustained efficacy in reducing pain and improving joint function, complicating therapeutic decisions.Aim — to evaluate the efficacy of OACS treatment, as measured by VAS, 12 months after the initiation of intra-articular PRP injection compared to HA injection.Materials and methods. We included only English-language articles with full text available that presented treatment outcomes as VAS in patients treated for OACS with...
Davide Previtali, ..., and G. Filardo
EFORT Open Reviews · 2025
Abstract: Purpose To quantify the response to intra-articular saline administration in terms of pain, function, and quality of life, with a focus on the evolution of placebo response over time and the identification of influencing factors on the placebo response to knee osteoarthritis injections. Methods After registration on PROSPERO, a systematic review was conducted following PRISMA guidelines to identify double-blind, placebo-controlled randomised clinical trials on intra-articular knee injections for knee osteoarthritis. The placebo response was evaluated through meta-analyses of VAS pain, WOMAC, KOOS, and responder rates at 1-, 3-, 6-, and 12-months on placebo arms of included trials. The evolution of...
Jiang-Yin Zhang, ..., and Hong-Chen He
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2024
No summary or abstract available
Anna L. Park, ..., and Anthony Luke
Journal of Cartilage & Joint Preservation · 2024
No summary or abstract available
Mary K. Richardson, ..., and N. Heckmann
European Journal of Orthopaedic Surgery & Traumatology · 2025
Abstract: Systematic reviews and meta-analyses evaluating platelet-rich plasma (PRP) injections are vulnerable to spin (i.e., misrepresentation of study findings). We sought to describe the incidence of spin in the abstracts of systematic reviews and meta-analyses reporting on PRP for knee osteoarthritis. A Preferred Reporting Items for Systematic Reviews and Meta-Analyses search was conducted in Embase, PubMed, and Cochrane databases to identify systematic reviews and meta-analyses on PRP injections for knee osteoarthritis. Data collected from abstracts included 21 types of spin as originally reported by Yavchitz et al., year and journal of publication, level of evidence, and Scopus CiteScore™. Associations between the...
W. Glinkowski, ..., and Pol-Iaha Study Group
Journal of Clinical Medicine · 2025
Abstract: Background: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage breakdown, synovial inflammation, and pain, which leads to significant disability. IAHA is widely used because of its viscoelastic properties, which restore synovial fluid homeostasis and reduce symptoms. However, emerging evidence suggests that IAHA exerts additional biological effects including chondroprotection, inflammatory modulation, oxidative stress reduction, and pain modulation, which may influence disease progression. Objective: This narrative review examines the biological mechanisms underlying IAHA’s role in OA management. The review explored IAHA’s effects on synovial fluid viscoelasticity, inflammatory cytokine modulation, cartilage preservation, oxidative stress regulation, and pain pathways, emphasizing the...
Chengjing Wang and Bowen Yao
European Journal of Medical Research · 2025
Abstract: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder affecting a significant portion of the elderly population. Despite the availability of various non-surgical and pharmacological treatments, their effectiveness is often limited by temporary symptom relief and lack of disease-modifying properties. Platelet-rich plasma (PRP) has emerged as a promising biological therapy for KOA, with preclinical evidence suggesting its potential to promote cartilage repair and modulate inflammation. This systematic review and meta-analysis aims to comprehensively evaluate the efficacy and safety of PRP injections in the treatment of KOA. A systematic literature search was conducted from January 1, 2021, to December 31, 2024,...
Lior Laver, ..., and Laura de Girolamo
Journal de Traumatologie du Sport · 2025
No summary or abstract available
Benjamin B Rothrauff, ..., and Johnny Huard
The American journal of sports medicine · 2026
Abstract: Platelet-rich plasma (PRP) is a blood-based orthobiologic used to treat a myriad of musculoskeletal conditions. While in vitro and preclinical studies on PRP have been promising, clinical results have been mixed. The heterogeneity in clinical benefits is attributable to both the complexity and variability of PRP as a biologic as well as the diversity of targeted tissues and ailments. Many variables have been proposed to affect PRP's bioactivity and clinical effects, with differing levels of evidence demonstrated for each variable. These variables can be broadly categorized as biological, technical, and abnormality-specific factors. Additionally, insufficient characterization of PRP in clinical studies...
Angelo Boffa, ..., and Giuseppe Filardo
The Knee · 2025
No summary or abstract available
A. Schwitzguebel, ..., and Charles Benaim
JMIR Research Protocols · 2024
Abstract: Background Available evidence on the conservative treatment of knee osteoarthritis still leaves questions about the efficacy of platelet-rich plasma (PRP) and whether stromal vascular fraction (SVF) offers a superior therapeutic tool. Objective This study aims to assess the clinical efficacy of SVF as adjuvant therapy to PRP on functionality and tissue regeneration for knee osteoarthritis. Methods In a multicenter, randomized, triple-blind, controlled trial, 108 individuals with knee osteoarthritis will be block-randomized in a 1:1 ratio. Patients will receive an initial single PRP or PRP + SVF injection followed by PRP doses at 1 month and 2 months. The primary endpoint...
I. Sekiya, ..., and N. Ozeki
PLOS One · 2025
Abstract: The regenerative effect of platelet-rich plasma injection on cartilage in knee osteoarthritis remains controversial. The purpose of this study was to use our recently developed 3D-MRI evaluation system to examine in detail the changes in cartilage thickness occurring six months after platelet-rich plasma injection. This study included 21 knees from 16 patients with medial knee osteoarthritis. An autologous protein solution (APS) was injected as platelet-rich plasma, and magnetic resonance imaging scans were taken before and six months after the injection. Cartilage thickness was quantified in seven regions using SYNAPSE 3D. Based on previous studies, the measurement error was set at...
Giulia Marcella Maryse Chiari Gaggia, ..., and Elizaveta Kon
Clinics in sports medicine · 2025
No summary or abstract available
Association of North America and the International Arthroscopy Association
2023
No summary or abstract available
Angelo Boffa and Giuseppe Filardo
Clinics in sports medicine · 2025
No summary or abstract available
Jacob L. Kotlier, ..., and F. Petrigliano
Arthroscopy, Sports Medicine, and Rehabilitation · 2024
No summary or abstract available
Matúš Sloviak, ..., and J. Gallo
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca · 2025
No summary or abstract available